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Diabetic peripheral neuropathy based on Schwann cell injury: mechanisms of cell death regulation and therapeutic perspectives

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doi: 10.1161/01.CIR.0000129501.88485.1f 171 LermanAZeiherAM

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In the first study, the Authors observed that GLP-1 levels were similar in PCOS and controls in the early phase of the 75-g oral glucose tolerance test (OGTT) until 60 min, but that GLP-1 levels were significantly lower after 180 min, suggesting that women with PCOS might have reduced GLP-1 secretion in the late postprandial phase [45]

In contrast, other studies have reported that NF-B may act as a downstream mediator of psilocins effects in microglia, as this transcription factor is known to regulate the expression of both NADPH oxidase (NOX) and inducible nitric oxide synthase (iNOS), which are responsible for ROS and NO production, respectively [15,46]