GLP-1 Physiology and Central Regulation of Appetite Nature Reviews Endocrinology 2
The precise mechanism of kidney-protective effects of GLP-1 RAs still remains elusive, but likely include direct kidney actions such as inducing natriuresis through NHE3 inhibition in the proximal tubules, suppressing the intrarenal renin-angiotensin system, ameliorating kidney ischemia/hypoxia [63, 64]
If patients do not tolerate a dose during dosage escalation, consider delaying dosage escalation
After a few weeks I felt ok but not completely myself and resigned mystic the fact this was better than nothing and would be almost myself forever
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