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In addition, there is evidence that pioglitazone reduces the risk of MI and acute coronary syndrome in patients with cardiovascular diseases (CVD) and patients with type 2 diabetes who had previous myocardial infarction [220,221,222]

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There is a theoretical concern that very high doses may interfere with certain chemotherapy drugs that rely on oxidative mechanisms, so individuals undergoing cancer care should consult their oncologist before supplementing

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