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Take, for instance, a 2009 study that found spermidine administration could inhibit oxidative stress and cell death in yeast, fly, worm, and even human cell cultures, resulting in "markedly extended" lifespans.9 Another of spermidines lifespan-extending qualities is its ability to boost nicotinamide adenine dinucleotide (NAD+), a coenzyme that can slow biological aging

Dresselhaus, E

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Previous studies have shown that IGFs play an important role in endothelial cell physiology by promoting the expression of the vasodilators NO, VEGF and hypoxia-inducible factor (HIF) (33,34)

10.1186/s12916-020-01697-5 BMC Med

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