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By activating the lactate transporter Slc5a12 on CD4 + T cells and inhibiting the expression of hexokinase 1 (HK1), lactate accumulation in synovial fluid (SF) reduced glycolytic flux in T cells and promotes FAS, which raises IL-17 production (152)

The expression levels of glucose transporters, glycolytic enzymes, and transcription factors related to glycolysis collectively influence the differentiation of T cell subsets (Fig

These findings not only enrich the molecular understanding of senescent cell clearance but also provide a novel strategy for precise targeting of endothelial cell senescence in therapeutic applications

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Furthermore, estrogen deficiency alters the profile of circulating signals from adipose, skeletal muscle, and the gut microbiome to stimulate hepatic inflammation and MASLD development (Fig