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It remains an experimental compound, and its full safety profile is still being established through ongoing Phase 2 and Phase 3 trials
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While Semaglutide GLP-1 has proven successful, tirzepatide has shown even better results in clinical trials
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Real-world data with behavioural support Second Natures peer-reviewed research, published in JMIR Formative Research (2025), showed that semaglutide, combined with registered dietitian support and a structured behaviour change programme, produced an average 19.1% weight loss at 12 months, with 77.7% of participants achieving at least 10% weight loss
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