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"Pernicious" means "harmful" or "destructive." This type of B12 deficiency anemia can affect many body systems and cause problems in your gut, heart, and muscles

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This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity

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