doi: 10.1164/ajrccm/145.3.651 72 Fernndez-TorresRGarca-SilvaJRoblesOOteroAVzquezMAFonsecaE
99 MaetaK.NomuraW.TakatsumeY.IzawaS.InoueY
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IFN- locally increases levels of CXCL9 and CXCL10 in the skin and serum of vitiligo patients, which in turn attracts pathogenic T cells expressing the CXCR3A receptor.18 A predominant lymphocytic infiltrate of CD8+ T cells has been observed in perilesional skin, correlating with disease activity.3 In vitiligo patients, CD8+ T lymphocytes recognize specific melanocyte antigens (MelanA, tyrosinase, gp100, tyrosinase-related proteins 1 and 2, Mart-1)