semaglutide non responders Why am I not losing weight on (Ozempic/Wegovy)? Semaglutide cardiovascular outcomes align more

It mimics a natural hormone called GLP-1 (glucagon-like peptide-1) that helps regulate blood sugar levels and appetite

Garvey WT, Mechanick JI, Brett EM, et al

But it happens without a physical blockage being present

Nunnari J, Suomalainen A

The resolution of this paradox likely involves dose, individual neurological vulnerability, and the difference between GLP-1 receptor activation in different nervous system compartments

For semaglutide, the main concerns include pancreatitis (rare but documented), gallbladder events (including gallstones, particularly during rapid weight loss), and a theoretical concern about medullary thyroid carcinoma based on rodent studies