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Vitamin B12 Deficiency: Insufficient dietary intake of B12 (common in vegetarians and vegans), Malabsorption due to conditions like pernicious anemia or gastrointestinal disorders (e.g., Crohns disease), Certain medications that interfere with B12 absorption can lead to deficiency

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And absent more rigorous studies, the team warned, it will remain difficult to convince the broader medical community that this so-called wonderful compound meets the criteria of a legitimate therapeutic agent. But it turns out, one group had begun to give it a go anyway

Brain lesions assessment Regularly, after 24 hours we found a heavy interstitial edema in all rat brains, particularly in the cerebellum and more so in white than in gray mater