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Transcription factors in ferroptotic cell death

In addition to the genetic information encoded by the primary DNA sequence, epigenetic mechanisms add a layer of regulation of the information and includes DNA methylation, histone modifications as well as regulation by non-coding RNAs (Karius et al., 2012

, & Kumar, S

Copyright 2008 Atherosclerosis

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The ex novo synthesis of NRF2 is triggered after exposure to low concentrations of H 2 O 2 , which precedes the translocation of NRF2 to the nucleus