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More studies are needed to examine how and why GLP-1 drugs with semaglutide as the active ingredient can put people at risk of blood clots and vision loss

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Examples of drugs that exhibit flow dependent hepatic clearance (high hepatic extraction ratio) include: Morphine , Lidocaine, Verapamil, Nitroglycerin, Propranalol Flow-Dependent Clearance The clearance of high-extraction drugs is primarily dependent on hepatic blood flow

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