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As ROS accumulate excessively, the mitochondrial outer membrane protein Tom20 and the Bax pathway are altered, leading to the release of cytochrome c and other pro-apoptotic/pro-pyroptotic molecules from mitochondria, thereby activating the downstream caspase cascade

& Tamura, T

Pernicious anemia is associated with an increased incidence of carcinoma of the stomach, but this is believed to be related to the underlying pathology and not to treatment with vitamin B 12

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Dose-normalized analyses further supported greater exposure per unit dose with LMG (e.g., up to ~4-fold higher iAUC and C max when expressed as a 300 mg equivalent