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Small number of research groups : A limited number of research groups have conducted most studies, which may affect the generalizability of the results

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Anecdotal reports from research subjects and biohacking communities describe body composition improvements, increased subjective energy and mental clarity, and minimal side effects, though these uncontrolled observations require cautious interpretation and cannot substitute for rigorous clinical trials

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showed that pre-treatment with vitamin B12 inhibited the increase in ALT serum levels in rats in which hepatotoxicity was induced by acetaminophen 31

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Bowers synthetic peptides, which had a similar effect, were called GHRPs, or growth hormone-releasing peptides

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The 4 mg/mL concentration (2.5 mL water) is less common but appears in some compounding pharmacy protocols

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