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While most men tolerate B12 well, those with Lebers disease (a rare genetic eye disorder) should avoid injections, as high doses of B12 may worsen symptoms

Several laboratory tests should be performed prior to treatment with cyanocobalamin, including serum vitamin B12, folate, iron, hematocrit, and reticulocyte count

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For those without contraindications of vitamin B12, the potential benefits of vitamin B12 supplementation are often deemed to outweigh the associated risks

Reduce training volume by 20-30% compared to maintenance-calorie periods