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The magnitude of this potential comes not just from the large apparent effect size for addiction reduction, which may or may not exceed that of existing treatments, but from the possibility of reaching a scale of adoption that far exceeds legacy therapies

A 2025 head-to-head study confirmed it: tirzepatide users lost 20.2% vs 13.7% for semaglutide

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When providers submit prior authorization requests, medical necessity documentation often becomes one of the most important factors influencing approval decisions

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