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The etiology of the production of autoantibodies is not entirely known, but it is clear that these antibodies may be formed against true self chromatin or formed due to infection-related DNA or DNA-binding proteins through molecular mimicry (45)

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In contrast, tofacitinib was associated with more significant elevations in liver function tests, highlighting apremilasts relatively favorable hepatic safety profile (Jadhav et al

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Cells were incubated at 37C in 5% CO 2 and 95% humidity and were used up to passage 25