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HHcy is suspected to cause neurotoxicity [75,76], and most neurological and psychiatric disorders appear to result from a combination of various genetic and environmental factors [77]

HDACs and SIRTs, by removing lactylation modifications, regulate the levels of lactylation in the CNS together with the writers

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Glutathione conjugation as a mechanism for the transport of reactive metabolites

The time to reach maintenance dose varies by medication, typically ranging from 4 weeks for some formulations to 1620 weeks for others such as semaglutide (Wegovy)