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ENT-01 ( squalamine phosphate ) inhibits -synuclein aggregation in the gastrointestinal tract and significantly increased the number of complete spontaneous bowel movements per week after 25 days on ENT-01 treatment in a double-blind, placebo-controlled, phase 2b RCT in 150 participants with PD and constipation however at the expense of gastrointestinal AEs in up to one third of participants [166]

The TGA has said some evidence suggests there is a lack of awareness that B6 can cause damage to the nerves outside the brain and spinal cord

2007 May;75(2):176-84

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Though this injection will provide outcomes for a longer time, you will need to receive booster dosages to maintain the effects