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Additionally, mucocutaneous reactions such as photosensitivity, pruritus, angioedema, vasculitis, and anaphylaxis have been reported

I never find a clear physical explanation, and I feel that leaves us with an interesting question as to whether Mpemba-like effects exist in a meaningful way. Bechhoefers trials appear to offer some insight into how the Mpemba effect could arise in systems with metastable states, but whether it is the only mechanism or how any particular substance undergoes such out-of-equilibrium heating or cooling is unknown

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However, some studies suggest glutathione may influence certain coagulation parameters, which could impact how these medications work

Turner, N.W., Bramhmbhatt, H., Szabo-Vezse, M., Poma, A., Coker, R., and Piletsky, S.A., Anal

doi: 10.1016/j.freeradbiomed.2021.09.001 78