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Chronic myelogenous leukemia, promyelocytic leukemia, polycythemia vera and hypereosinophilic syndrome have all been associated with high B12 levels (25)
Eduardo Javier R
At the molecular level, 5-amino-1MQ functions as a competitive inhibitor of NNMT, demonstrating remarkable potency with an IC of 1.2 0.1 M under standard assay conditions (50 M SAM, 100 M nicotinic acid). This represents a dramatic 10-fold improvement over the parent compound 1-methylquinolinium, achieved through strategic amino group substitution that enhances binding affinity to the NNMT active site. The compound's mechanism centers on preventing the methylation of nicotinamide to 1-methylnicotinamide (1-MNA), thereby preserving nicotinamide for recycling back to NAD+ through the salvage pathway. This intervention effectively blocks what researchers have termed the "NNMT metabolic drain" a process that simultaneously depletes NAD+ precursors and consumes cellular methylation capacity

Finally, social media and online patient forums often discuss nutritional concerns related to GLP-1 receptor agonists, sometimes spreading misinformation or conflating different medications and their effects
If you have ever been told by your doctor or nurse that you are addicted to B12, you will hopefully forgive my tongue in cheek loose analogy with cannabis