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The results of another randomized trial in 39 patients with Alzheimers disease suggested that supplementation with fish oil concentrate (high in omega-3 fatty acids) with or without lipoic acid (600 mg/day) for one year could delay the progression in cognitive and functional impairments assessed by the Instrumental Activities of Daily Living (IADL) scoring system compared to placebo (104)

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Measurement of prothrombin fragment 1 + 2 by ELISA The presence of a hypercoagulation state was evaluated by measuring the level of prothrombin fragment 1 + 2 using a Human Prothrombin Fragment 1 + 2 (F1 + 2) ELISA Kit (MyBioSource, Inc., San Diego, CA, USA), according to the manufacturer protocol

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