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Aqueous-based synthesis, an emerging alternative to SPPS, is a potential answer

JAMA, 325(14), 14141425

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Third-party purity testing (HPLC & MS) U.S.-based fulfillment Published COAs per lot View Supplier References Literature & Citations Sikiric P, Hahm KB, Blagaic AB, et al

In studies, L-theanine has shown a great safety profile, with animal studies employing doses that equate to around 50g/day in humans without any side effects.6 Another study, which combined L-theanine or placebo with the anti-anxiety medication fluoxetine, reported only mild drowsiness and occasional GI upset.7 Studies into Suntheanine bear similar results