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1 Introduction Cystic fibrosis (CF), caused by mutations in the cystic fibrosis conductance regulator ( CFTR ) gene, is the most common rare disease affecting the Caucasian population, with an incidence of 2,5003,500 newborns (Saint-Criq and Gray, 2017)

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J Clin Invest (2007) 117:3393402 10.1172/JCI31547 [DOI] [PMC free article] [PubMed] [Google Scholar] 51.Danielyan L, Klein R, Hanson LR, Buadze M, Schwab M, Gleiter CH, et al

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