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MOTS-c activates AMPK (AMP-activated protein kinase), which signals cells to shift from glucose storage to fat oxidation and improves insulin sensitivity through mitochondrial and nuclear gene regulation

doi: 10.1097/WOX.0B013E3182439613 11 JopkiewiczS

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Oligodendroglial myelination requires astrocyte-derived lipids

For type 1 diabetes patients considering tirzepatide for weight management (which has become more common as insulin therapy-related weight gain is a recognized problem), the primary concern is hypoglycemia risk