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The results of another randomized, double-blinded, placebo-controlled trial suggest that oral melatonin, combined with the first adjuvant chemotherapy for breast cancer (ACBC), can counteract dysfunction of the inhibitory descending pain regulatory system (DPMS) and reduce serum levels of neuronal and astrocyte neuroplasticity markers (i.e., BDNF, S100B proteins, and TrkB), thus improving pain perception indicators [58]

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