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GLP-1 short-term side effects include: Nausea Vomiting Diarrhea Constipation Headaches Fatigue Dizziness GLP-1 long-term side effects include: Ongoing and persistent irregular bowel movements Sluggish digestion Changes in gut comfort over time Impact on bone health and density Reduction in muscle mass Nutritional deficiencies Its important to note that long-term GLP-1 medication side effects have not been well-studied