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In patients with HFpEF and obesity, both semaglutide and tirzepatide improve NYHA class, physical function, and quality of life independent of glycemic control, suggesting a glucose and weight-independent mechanism linked to anti-inflammatory and hemodynamic effects [5, 11]

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622 Clinical imaging showed increased iron signaling in the basal ganglia and decreased iron in the white matter and cortex in HD patients

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Intriguingly, GLP-1 is secreted by intestinal cells not only in response to food but also to "inflammatory stimuli," and its levels correlate with disease severity in inflammation

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