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We demonstrate a host of novel neurochemical abnormalities consistent with schizophrenia-like phenotypes and our observed cognitive and electrophysiological cortical alterations

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In contrast to other opioids like morphine, mitragynine and 7-hydroxymitragynine selectively activate the G-protein second messenger upon binding to the G-proteincoupled receptor rather than the -arrestin-2 signaling pathway, which is responsible for many of the adverse effects associated with typical opioids

Gut feedback mechanisms and food intake: a physiological approach to slow carbohydrate bioavailability