Because the two are not identical, confirming the exact amino acid sequence on the Certificate of Analysis (COA) is essential before any comparative work
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Moreover, the increase in reactive oxygen species (ROS) and reactive nitrogen species (RNS) in endothelial cells due to systemic inflammation might alter claudins and occludins, which are critical structural components of the BBB
20 Although the treatment of PSM of extramedullary origin has not yet been standardized, most researchers recommend total surgical resection