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Oral L-carnitine supplementation and exercise performance

The success of these therapies has paved the way for the development of next-generation treatments, including multi-agonist molecules like Tirzepatide (Mounjaro/Zepbound) or Retatrutide (LY3437943) that simultaneously target several metabolic receptors to achieve improved metabolic outcomes in obese or diabetic patients [3,6]

Kishimoto K, Li RC, Zhang J, Klaus JA, Kibler KK, Dor S, Koehler RC, Sapirstein A (2010) Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice

This mechanism reduces appetite and calorie intake but does not directly affect muscle metabolism or creatine uptake

Factors like food access, safe housing, living wages, high-quality healthcare, and coverage for dietitians all matter just as much

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