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While mtROS generation serves as a signaling cue for immune activation, excessive accumulation leads to oxidative stress, mtDNA damage, and mitochondrial permeability transition

Similar to the findings of other studies in the STEP trial program 7,27 , exploratory outcomes showed that in the semaglutide group 80% of participants with prediabetes at baseline reverted to normoglycemia by the end of the trial (compared with 37% of those receiving placebo), while 99% of participants with normoglycemia at baseline maintained normoglycemia at the end of the trial (compared with 86% with placebo)

This specificity allows for drug delivery directly to the tumor

10.1055/s-2006-957065 68 HodgsonJ

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