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Nature Medicine (2015) 10.1038/nm.4000 Comprehensive review of cellular senescence as a driver of age-related pathology and the therapeutic potential of senolytic approaches, providing context for FOXO4-DRI's significance
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Too much or too little iron can lead to cell damage
In addition, GSH depletion induced SIPS, as evidenced by increased percentage of the senescence-associated -galactosidase-positive cells, increased senescence-associated heterochromatin foci (SAHF), as well as cell cycle arrest at the G1 phase
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