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Key factors include: (1) Pro-inflammatory cytokines: Cytokines such as TNF and interleukin-1 beta (IL-1) are known to activate NF-B, leading to increased EAAT3 expression

For example, Sheng et al

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

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These environmental stressors generate free radicals that accelerate cellular aging