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3 The ferroptosis pathway 3.1 Definition and distinctive features Ferroptosis is a form of regulated cell death characterized by the accumulation of iron-dependent lipid peroxides, distinct from apoptosis, necroptosis, and autophagy

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Affinity purification and mass spectrometry analysis have shown that Erastin interacts with voltage-dependent anion channel 2 (VDAC2) (103), reducing the permeability of VDAC2 to the reduced form of nicotinamide adenine dinucleotide (NADH), altering its ion selectivity, and disrupting mitochondrial respiratory chain oxidative phosphorylation (104)

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