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Sixty sedentary (BMI 27.13.9kg/m 2 ) elderly volunteers (age 66.91.2yrs, MMSE score 28.21.2) were subjected to either 3-month supervised aerobic-strength training (3x1h/week) (n=36) or stretching exercise training (n=24, active controls)

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Evidence that systemic NAD pools undergo inter-organ redistribution and dynamic turnover [96, 107, 126] supports the view that redox stability reflects flux kinetics rather than static metabolite concentrations

However, no significant increase in the risk of serious biliary tract disease has been observed

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