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Developing drugs that can activate central GLP-1 pathways effectively and for longer durations and ensuring they cross the bloodbrain barrier remains a major challenge

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Meanwhile, average annual treatment costs for oncology and rare diseases [are] both approaching $300,000 per patient. A SEQUEL TO BIG PHARMAS PRICE-GOUGING ON DIABETES DRUGS GLP-1s grew out of a category of medicines originally designed for treating diabetes

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Another potential issue is that beneficiaries who participate in the short-term program will need to be enrolled in a Part D plan that participates in the longer-term demonstration, called the BALANCE Model, to continue accessing Medicare coverage of GLP-1s for obesity starting in 2027