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Proposed Mechanism BPC-157 appears to work through multiple pathways: Maintaining vesicular integrity (affecting VMATs and dopamine transporters) Possibly occupying its own vesicular storage sites Competing for dopamine receptor binding Functionally substituting when dopaminergic neurons are lost This last property, essentially filling in for missing dopamine function, would explain why the peptide counteracts both receptor agonists (apomorphine) and antagonists (haloperidol, fluphenazine, clozapine, sulpiride) with equal effectiveness

4 Journal of Human Kinetics

The skin alkali burn was made by placing a 9 cm 2 piece of filter paper soaked in 2 M NaOH on each animals skin for 75 seconds

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For vascularization, the following scoring was used: score 0: a delicate network of small arteries oriented parallel to collagen fibers within the thin connective septa between the bundles

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