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Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin
A prospective cohort study involving 266 elderly adults treated with epithalamin (the parent compound from which Epithalon was derived) over 2-3 years with subsequent 4-5 year follow-up demonstrated mortality reduction of 28% overall, with a 2-fold decrease in cardiovascular disease-specific mortality
Recinella L, Orlando G, Ferrante C, Chiavaroli A, Brunetti L, Leone S (2020) Adipokines: new potential therapeutic target for obesity and metabolic, rheumatic, and Cardiovascular Diseases
From a therapeutic standpoint, several strategies aimed at restoring hepatic thyroid hormone action and correcting ECM dysregulation are under investigation