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Do not use if you or a family member has ever had medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) because tirzepatide may increase thyroid tumor risk

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Diabetes enhances BBB leakage due to tight junction protein loss, but hyperglycemia is not the only damaging factor responsible for increased BBB leakage in diabetes

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Further metabolic control analysis in 2023 explained the mechanism behind this massive increase