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Although protective drugs have also been discovered, the studies had limitations, including their small sample sizes and failure to explore the mechanisms in-depth, and the clinical relevance of the findings has yet to be verified

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Common cycling patterns include five days on with two days off, or continuous use for 4-8 weeks followed by a rest period

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Clinical trials demonstrated 13.7 percent average body weight loss at 72 weeks, with many participants exceeding 15 percent