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2019) are expressed in murine astrocytes and contribute to the remarkable ability of these brain cells to efficiently detoxify applied peroxides with halftimes in the minute range (Dringen and Hamprecht 1997

POR can generate ROS by extracting hydrogen from PUFAs or reducing Fe 3+ to Fe 2+ , reacting with adjacent lipids to form lipid hydroperoxides [38]

Inadequate protein during caloric restriction leads to muscle loss rather than fat loss

Finally, this review will summarize challenges of prescribing RT interventions (i.e., feasibility, adoption, adherence) in healthy and older adults at risk for ADRD and provide recommendations to overcome these challenges

Protocol 3: side effect management Goal: Minimize digestive side effects that are limiting adherence or quality of life

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