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Activated protein C is a natural anticoagulant that will degrade activated factor V (factor Va)
The oxidative modification of proteins is mainly reflected in the amino acid side chain, which leads to the formation of carbonyl groups [133, 134, 135]
However, therapeutic doses for treating deficiency range from high-dose oral supplements (1,0002,000 g daily) to intramuscular injections of 1 mg, particularly for pernicious anaemia or malabsorption conditions
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Nonetheless, mice deficient for GRP have impaired glucose tolerance, reduced first-phase insulin secretion and impaired GLP-1 secretion in response to an oral glucose challenge [343]
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