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& Avery, S

& Giuffre, A

He helped me in so many ways

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64,65 Notably, ERdj4, ERdj5, and GRP170 selectively recognize a distinct type of rarer peptide that contains high levels of aromatic residues and tends to form aggregates, which directs the client protein from pro-folding to pro-degradation

In general, but not necessarily, the homozygous variant, often the minor allele, may confer to the affected individual a higher susceptibility in comparison with the homozygous wild-type and heterozygous condition, particularly in the occupational context wherein the exposure to chemical and physical agents may worsen the disorder