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Retatrutide is a triple hormone (GIP, GLP-1 and glucagon) receptor agonist in development for the treatment of obesity

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Notably, semaglutide reduced BP in normotensive Glp1r Tie2+/+ and Glp1r Tie2/ mice (Figure 3, GI, and Supplemental Figure 5, DF), indicating that GLP-1R expression in Tie2 + cells is not required for semaglutide-mediated reduction of BP in healthy mice

A lyophilized peptide is relatively resilient, but it's not invincible