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Whether the discrepancy in results of these studies is due to the use of native GLP-1 vs

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Tirzepatide is the active ingredient in brand-name Mounjaro (approved for type 2 diabetes) and Zepbound (approved for chronic weight management)

Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use

Based on clinical studies: 25-55% reduction in wrinkle depth/volume after 8-12 weeks, 70% increase in skin elasticity, 28% increase in collagen density