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Lycopene antagonizes lead toxicity by reducing mitochondrial oxidative damage and mitochondria-mediated apoptosis in cultured hippocampal neurons

Oral semaglutide and cardiovascular outcomes in high-risk type 2 diabetes

Diabetes Metab Syndr Obes 16:24332446 Volpe S, Lisco G, Fanelli M, Racaniello D, Colaianni V, Lavarra V et al (2023) Oral semaglutide improves body composition and preserves lean mass in patients with type 2 diabetes: a 26-week prospective real-life study

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The appetite effect the one that matters most for weight runs through the gut, the hypothalamus, and the brain's reward circuitry

Its perturbations, particularly in the synapse culminated hyperexcitability in the postsynaptic neurons and sustained seizure activity with consequential excitotoxicity and neuronal cell death