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Preclinical models found that GLP-1 RAs reduce intestinal inflammation in dextran sulfate sodium (DSS)-induced colitis, by increasing IL-22 production by colonic IELs and several beneficial bacteria, including Firmicutes, Proteobacteria and Lactobacillus reuteri (93)

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This can be achieved through various methods such as sonication, freeze-thaw cycles, enzymatic digestion (e.g., lysozyme treatment), or mechanical disruption (e.g., French press)

doi: 10.1126/science.1244360 171