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10.1111/j.1600-079X.2006.00377.x J

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Moreover, the clinic data indicated that the level of BDNF is markedly reduced both in plasma and post-mortem brains of patients suffering from schizophrenia, suggesting that dysfunction of BDNF plays a significant role in the pathogenesis of this disease (33)

In the human condition Fanconi Anaemia, metabolic ROS were shown to induce DNA damage in hematopoietic stem cells (HSCs) when they start cycling to exit quiescence, which impairs blood production in FancA / mice 51