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In the anabolic methionine cycle, niacin, in the form of NAD, is a necessary co-factor for the enzymes dihydrofolate reductase in the folate/tetrahydrobiopterin cycle and S-adenosylhomocysteine hydrolase (1)

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Arguments Against the FDAs Decision: Potential Health Benefits: Advocates emphasize the reported benefits observed in animal studies and limited human use, arguing these should be weighed alongside regulatory concerns